Lipid nanoparticle mediated gene delivery for hematological disorders

Location Amsterdam Working week 36-40 hours
Education PHD Closing date 03 March 2025
Function area Research / Laboratory Vacancy nr. 1386
Sanquin Blood Supply Foundation uniquely combines medical, diagnostic, blood bank and research activities. With 2,000 committed colleagues and 345,000 blood donors, we aim to provide a better life for 300,000 patients each year.

The Division of Research and Lab Services of Sanquin is home to 250 researchers, including over 60 PhD students and 30 postdocs. Research at Sanquin is organized in four strategic themes: Anemia, Bleeding & Hemostasis, Immunity & Inflammation, and Immune Therapy. The joint mission of research at Sanquin is to novel methods and approaches using blood cells and blood products to prevent, diagnose, treat, or cure disease in donors and patients. Research activities cover the full spectrum of early inventions, development into novel products and services, donor studies, and clinical studies in patients.

Our research labs are equipped with state-of-the-art facilities, including flow cytometry and cell sorting, macromolecular mass spectrometry and proteomics, and imaging. Many of our scientists have academic affiliations with Dutch Universities and University Medical Centers. Sanquin is strategically located in Amsterdam, with a special link to the AmsterdamUMC (Joint Landsteiner Laboratory). Gene therapy program Sanquin

The gene therapy group within Sanquin focuses on further improvement of the quality of life of patients with hematological disorders. Within our program we have now an opening for an expert on lipid nanoparticle mediated gene delivery to hematopoietic stem cells and other cells and tissues. In this novel line of research we specifically aim to establish non-viral approaches for in vivo targeting of hematopoietic stem cells. For this highly synergistic program we are looking for a postdoc with experience in nanoparticle mediated gene delivery, mRNA based therapeutic strategies and gene-editing.

Our expectations

We anticipate the newly recruited postdoc to contribute with her/his unique expertise, complementing our existing research portfolio. This includes inflammation and complement research as well as genetic and cellular approaches to correct and cure hematological disorders.

Our offer

We offer an international - academically oriented - research environment with state of-the-art equipment. You will have the opportunity to apply for external funding and further help to extend the highly collaborative (inter)national network and research activities of the Gene Therapy Program of Sanquin.

• A challenging translational project in a multi-disciplinary and enthusiastic international team;

• Temporary position (project duration of 3 years);

• Salary and conditions are conform CAO Sanquin;

• 8.33% end-of-year bonus; i.e. a thirteenth month in case of full-year employment;

• Partial reimbursement of travel costs.

• Pension plan with Pensioenfonds Zorg & Welzijn (PFZW), Sanquin contributes 65%;

• A fulltime employment (36 hours) 201 hours of leave per annum.

Applications

If you are interested in this position, please apply by submitting your extended CV before March 7. More information can be obtained from the website (www.sanquin.org/research/research-vacancies) or by sending an email to the Prof. dr. Jan Voorberg (j.voorberg@sanquin.nl) and Dr. Despoina Trasanidou (d.trasanidou@sanquin.nl).

A pre-employment screening will be part of the onboarding procedure.

Acquisition is not appreciated. Sanquin does not accept unsolicited help from agencies for vacancies. CVs sent (in any form whatsoever) by placement agencies to any Sanquin employee without a valid written assignment by HR Sanquin will be considered property of Sanquin for which no compensation is owed in any way..